Unique Spindle Poisons, Curvularin and Its Derivatives, Isolated from Penicillium Species

Akio KobayashiDepartment of Agricultural Chemistry, Okayama University, Okayama700, Japan

Tomokazu HinoDepartment of Agricultural Chemistry, Okayama University, Okayama700, Japan

Shinji YataDepartment of Agricultural Chemistry, Okayama University, Okayama700, Japan

Tomohiko J. ItohSugashima Marine Biological Laboratory, School of Science, Nagoya University, Toba-shi, Mie517, Japan

Hidemi SatoSugashima Marine Biological Laboratory, School of Science, Nagoya University, Toba-shi, Mie517, Japan

Kazuyoshi KawazuDepartment of Agricultural Chemistry, Okayama University, Okayama700, Japan

Abstract

Curvularin, 8-dehydrocurvularin, and 8-hydroxycurvularin as well as a minor new metabolite, 8-methoxycurvularin, were isolated as fungal metabolites having cytotoxic activity toward sea urchin embryogenesis. Curvularin induced barrel-shaped mitotic spindles and 8-dehydrocurvularin caused miniature spindles. They were shown to act on components of the mitotic apparatus and to effectively inhibit cell division.

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Unique Spindle Poisons, Curvularin and Its Derivatives, Isolated from Penicillium Species

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Unique Spindle Poisons, Curvularin and Its Derivatives, Isolated from Penicillium Species

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