Abstract
Pulmonary edema was produced in normal rats by the injection of a dose of alpha naphthyl thiourea (ANTU) which killed 27% of the animals. The same dose of ANTU administered to rats handicapped by a reduced pulmonary reserve (oleothorax) or by pneumoconiosis resulted in a 60% mortality. This increased mortality rate supports the hypothesis (applied to smog deaths) that individuals with an appreciably reduced pulmonary reserve or with significant pneumoconiosis are more vulnerable to pulmonary edema-producing irritants than are normal individuals.