Animals were exposed 58 times to dimethylformamide for 5.5 hours at 23 ppm followed by 0.5 hour at 426 ppm. No clinical signs of toxicity were observed in rats, mice, rabbits, or guinea pigs. Observed effects led to conclusion that the superimposed, short-term, peak exposure produced a hazard. Authors conclude that safe exposures for humans should not exceed 20 ppm, temporary peaks should be kept to a minimum, and workers should have respiratory protection during peaks.
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