Abstract
Carcinogenic and acute toxicity potential were assayed while more than 60 epoxy compounds were being studied for commercial utility. Range-finding toxicity data are presented for 60; lifetime mouse skin painting results are given for 28, and mouse sebaceous gland suppression results are listed for 26 of these compounds. None of the 11 monoepoxides produced tumors while 5 of the 17 diepoxides were tumorigenic during lifetime skin painting of mice. The median latent period for tumor production with the diepoxides was 15 to 23 months. No generalities about the toxic, irritative or carcinogenic hazards are justified by the presently known facts. Each compound must be individually studied to determine toxicity and carcinogenicity potential.
