Abstract
Rats, guinea pigs, rabbits and dogs were exposed seven hours per day, five days per week for a period of 16 weeks to either 5,000 or 1,000 ppm of a mixture of saturated and unsaturated C3 and C4 hydrocarbons (MAPP Industrial Gas®). There were no adverse effects on either sex of any species exposed to 1,000 ppm as determined by growth, mortality, body and organ weights, clinical and biochemical determinations, urinalysis, hematological examination, and gross and microscopic pathological examination. Questionable and presumably reversible changes were seen only in the male rats and guinea pigs exposed to 5,000 ppm.
Results of the limited sensory perception study on humans indicated that some persons could detect 25 ppm and most would detect 100 ppm. The odor was found to be strong at 1,000 ppm and quite objectionable at higher concentrations.