Abstract
Exposures to metallic particulates, individually and in alloys, along with mineral particulates may give rise to an electromotive phenomenon wherein high levels of biologically active cations are produced at localized tissue sites. The relative position of the involved metals in the electromotive series along with the nature of the associated metals and other minerals will influence the nature and concentration of the cations. This phenomenon may account for otherwise unexplained exacerbations of diseases, sensitization reactions, carcinogenicity, latency periods, and other responses. The potential role of this phenomenon in exposure to metals in asbestos is recognized, and supporting data are presented.