Abstract
Isoprene and methanol are two of the many compounds of toxicological interest found in the vapor phase of cigarette smoke. This study deals with the handling of these compounds by the respiratory tract of the dog. Specific objectives included determination of uptake of each substance by the entire respiratory tract and by upper and lower portions under varying conditions of ventilatory rate, tidal volume and concentration inhaled. Retention of isoprene by the total respiratory tract was about 65% regardless of rate, methanol uptake was about 20% higher. Upper and lower-tract retention of isoprene was higher than methanol uptake. Experiments concerning concentration and tidal volume were also carried out.