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American Industrial Hygiene Association Journal Volume 37, 1976 - Issue 2
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Original Articles

Toxicity and metabolism of methyl n-butyl ketone

M. S. ABDEL-RAHMAN The Ohio State University, College of Medicine, Department of Pharmacology, Toxicology Division, Columbus, Ohio 43210
,
L. B. HETLAND The Ohio State University, College of Medicine, Department of Pharmacology, Toxicology Division, Columbus, Ohio 43210
&
D. COURI The Ohio State University, College of Medicine, Department of Pharmacology, Toxicology Division, Columbus, Ohio 43210
Pages 95-102 | Published online: 04 Jun 2010
 

Abstract

MEK (2-butanone) when combined with MBK (2-hexanone) markedly enhanced MBK neurotoxicity. MBK in rat plasma after exposure to MBK/MEK increased with time. Metabolites of MBK identified in blood and urine of rats and guinea pigs were 2-hexanol and 2,5-hexanedione.

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