Experimental evaluation of the clearance of 3,4-benzo(a)pyrene in association with talc from hamster lungs

Abstract

B(a)P was administered intratracheally either alone or in association with 3 mg or 9 mg of talc, to Syrian golden hamsters. The clearance rate of the polycyclic hydrocarbon from the lungs was measured at regular intervals. It was found that talc was an effective factor in depressing the clearance of carcinogen from the lung tissue.