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American Industrial Hygiene Association Journal Volume 38, 1977 - Issue 11
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Original Articles

Results of a two year chronic toxicity study with hexachlorobutadiene in rats

R.J. KQCIBA Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
D.G. KEYES Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
G.C. JERSEY Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
J.J. BALLARD Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
D.A. DITTENBER Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
J.F. QUAST Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
C.E. WADE Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
C.G. HUMISTON Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
&
B.A. SCHWETZ Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
 show all
Pages 589-602 | Published online: 04 Jun 2010
 

Abstract

Lifetime ingestion by rats of 0.2 mg/kg/day of hexachlorobutadiene caused no discernible ill effects. Slight degrees of primarily renal toxicity occurred with 2 mg/kg/day; 20 mg/kg/day caused multiple toxic effects, including renal tubular neoplasms

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