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American Industrial Hygiene Association Journal Volume 60, 1999 - Issue 2
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Original Articles

Structure and Validation of a Pharmacokinetic Model for Benzene

Georgia C. Sinclair Occupational Hygiene Unit, Deakin University, Waurn Ponds, Victoria, Australia, 3217; [email protected]
,
Chris N. Gray Occupational Hygiene Unit, Deakin University, Waurn Ponds, Victoria, Australia, 3217
&
R. Jerry Sherwood Honey Bottom, Dry Sandford, United Kingdom, OX13 6BX
Pages 249-258 | Published online: 04 Jun 2010
 

Abstract

A pharmacokinetic model for benzene has been developed and validated for the inhalation aspects of its operation. The validation shows reasonable agreement between the model outputs and human biological data for phenol in urine, benzene in alveolar air, and benzene in mixed exhaled air.

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