Novel Pre-Oxidizing Cell for Elimination of Electroactive Interferents During Biosensor Analysis. Application to Glucose Determination in Real Samples

ABSTRACT

The application of a pre-oxidizing cell for the on-line elimination of electrooxidizable interferents in a flow-system equipped with an amperometric biosensor is presented. The reactor cell is based on vitreous carbon foam with large surface areas for the fast oxidation of electroactive compounds. The efficiency of the cell is evaluated using the most significant interferences found in real samples, those of ascorbic acid, uric acid and acetaminophen. The application of the cell, in the online analysis of glucose in real samples is finally demonstrated. The results are in agreement with those obtained by chromatography measurements (correlation coefficient: 1.04±0.02).

Keywords::

• Pre-oxidizing cell
• Interferents
• Amperometric Biosensor
• Real-analysis