Electrochemical Device for the Rapid Detection of Genotoxic Compounds in Fish Bile Samples

Abstract

The scientific goal of the present work is the development of a new molecular biomarker as a biomonitoring tool for early assessment of the biological effect of complex mixtures of pollutants (especially polycyclic aromatic hydrocarbons) and validation of the approach by comparison with standard methodologies. Hence, a DNA‐based biosensor, which is able to detect the presence of compounds with affinity for DNA to measure their effect on the guanine base, was used in this research.

Keywords:

• DNA biosensor
• fish bile
• PAH
• aquatic pollution

Acknowledgments

The authors are grateful to projects NFR‐PROOF 153898/40 and 164427/S40 and to TOTAL E&P Norge A/S for financial support, sample providing, and travel expenses within this research.