Highly Sensitive Electrogenerated Chemiluminescence Isoniazid with NiO Nanoparticles‐modified Graphite Electrode

Abstract

NiO nanoparticles (NiO NPs) were prepared with chemical precipitation method and modified on the surface of vaseline‐impregnated graphite electrode with chitosan. It was found that, based on the catalysis of the NiO NPs for the chemiluminescent reaction of the ECL process, the enhancing effect of isoniazid on the weak electrogenerated chemiluminescence (ECL) signal of luminol at a NiO NPs‐chitosan modified electrode was stronger than that at a bare graphite electrode. Under the optimum experimental conditions, the relative ECL intensity was linear with isoniazid concentration over the range 3.0×10⁻¹⁰∼1.0×10⁻⁶ g/ml at the NiO NPs‐chitosan modified electrode with a detection limit of 1.0×10⁻¹⁰ g/ml.

Keywords:

• NiO nanoparticles
• electrogenerated chemilumescence
• luminol
• isoniazid
• catalysis