![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
The nanocomposites of gold nanoparticles and multi‐walled carbon nanotubes (MWCNTs) have been applied in the enhanced electrochemical detection of DNA hybridization. Gold nanoparticles coated on MWCNTs uniformly were synthesized by simply one step reaction. Target DNA was detected by the peak current difference of differential pulse voltammetry (DPV) signals of the electroactive indicator methylene blue (MB) before and after hybridization on the Au/MWCNTs modified glass carbon electrode (GCE). Due to the excellent electrical conductivity of the novel matrix, the biosensor revealed high sensitivity with the detection level down to 1.0 pM. Excellently selectivity and reproducibility were also discussed.
This work has been supported by National Natural Science Foundation of China (Project Nos. 60574095, 10635070, 90406024)(Project Nos. 60574095, 10635070, 90406024), National High Technology Research and Development Program of China (Project No. 2006AA03Z309), and The Knowledge Innovation Program of the Chinese Academy of Science (Project No. kjcxz‐sw‐h12‐02), which are gratefully acknowledged.