Electrochemical Oxidation of Pentoxifylline and its Analysis in Pure and Pharmaceutical Formulations at a Glassy Carbon Electrode

Abstract

The oxidative behavior of pentoxifylline was studied at a glassy carbon electrode in phosphate buffer solutions using cyclic and differential-pulse voltammetry. The oxidation process was shown to be irreversible over the pH range (3.0–9.0) and was diffusion controlled. The possible mechanism of the oxidation of pentoxifylline was investigated by means of cyclic voltammetry and UV-Vis spectroscopy. An analytical method was developed for the determination of pentoxifylline in phosphate buffer solution at pH 3.0 as a supporting electrolyte. The anodic peak current varied linearly with pentoxifylline concentration in the range 2.0 × 10⁻⁸ M to 6.0 × 10⁻⁷ M of pentoxifylline with a limit of detection (LOD) of 4.42 × 10⁻¹⁰ M. The proposed method was applied to the determination of pentoxifylline in pure and pharmaceutical formulations.

Keywords:

• Drug analysis
• Glassy carbon electrode
• Oxidation mechanism
• Pentoxifylline
• Voltammetry

This work is supported by the University Grant Commission, New Delhi, (No. F.30-66/2004 (SR) dated 10-11-2004) and the Special Assistance Programme (Phase II) (No. F-540/13/DRS/SAP-I Dated 28-01-2005).

Notes

^a Names of the tablets.

^b Each value is the mean of five experiments.

^c Recovery value is the mean of five experiments.