Europium(III)-Sensitized Chemiluminescence Determination of Ibuprofen in Pharmaceutical Preparations and Biological Fluids

Abstract

Chemiluminescence reaction of the system containing europium(III) ion, KMnO₄, Na₂SO₃, and ibuprofen was investigated for the determination of ibuprofen. The introduction of Eu(III) ion into the system of KMnO₄-Na₂SO₃-ibuprofen caused a significant increase in the chemiluminescence signal. The increment of the chemiluminescence signal is proportional to ibuprofen concentration in the range of 5.0 × 10⁻⁸–5.0 × 10⁻⁶ g/ml with a detection limit of 1 × 10⁻⁸ g/ml. The relative standard deviation for 1.0 × 10⁻⁷ g/ml ibuprofen solution was 1.7% (n = 11). The proposed method was successfully applied to determine ibuprofen in tablets and human plasma.

Keywords:

• Chemiluminescence
• Europium(III) ion
• Ibuprofen