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TBC

Determination of Camphor and Borneol in Traditional Chinese Medicines by Microwave-assisted Extraction and Gas Chromatography with Flame Ionization Detector

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Pages 2387-2401 | Received 13 May 2008, Accepted 12 Jun 2008, Published online: 05 Nov 2008
 

Abstract

In this work, microwave-assisted extraction (MAE) followed by gas chromatography with flame ionization detector (GC–FID) was developed for the rapid determination of camphor and borneol in three traditional Chinese medicines (TCM): Chrysanthemi indici, Flos Chrysanthemi indici and Amomum villosum lour. The optimal MAE conditions obtained were: acetone for solvent, with solvent having sample ratio of 12:1 (v/w); microwave power of 380 W, and an irradiation time of 4 min. Method validations were also studied. To demonstrate the proposed method, ultrasonic-assisted extraction (UAE) and steam distillation (SD), followed by GC-FID, were used to analyze camphor and borneol in thethree TCMs. The close results were obtained by the three methods. The results showed that the proposed MAE–GC–FID is a simple, rapid, and reliable method for quantitative analysis of camphor and borneol in TCM, and is also a potential tool for TCM quality assessment.

The work was supported by NSFC (20875017), PCRRFO5001, and Shanghai Leading Acadmic Discipline Project (B109).

Notes

a Chrysanthemi andici

b Flos chrysanthemi indici

c Amomum villosum lour

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