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Abstract
A solvothermal method has been used to synthesize anatase-type TiO2 nanoparticles (NPs) using ionic liquid (1-ethyl-3-methylimidazolium-ethyl sulfate) as cosolvent and modifier. Palladium nanoparticles were electrodeposited on the glassy carbon (GC) electrode modified with synthesized TiO2 nanoparticles/chitosan film in the presence of glycin. The resulting amperometric sensor was used for direct determination of uric acid in human serum samples. Ionic liquid, TiO2, and Pd nanoparticles were characterized by infrared spectra (IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). This sensor offered an excellent detection for uric acid at 0.60 V in a linear response range of 4.42 × 10−5 to 7.98 × 10–3 M with a correlation coefficient of 0.997. The sensor displays rapid response, expanded linear response range, excellent repeatability, and excellent stability.
This work was supported by the Foundation of Science Commission of Yunnan Province (No. 2006B0028M) and the Foundation of Department of Education of Yunnan Province (No. 07Z10087).