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BIOANALYTICAL

Novel Detection Method of Endocrine Disrupting Chemicals Utilizing Liposomes as Cell Membrane Model

, &
Pages 2923-2932 | Received 25 Jul 2008, Accepted 10 Aug 2008, Published online: 02 Dec 2008
 

Abstract

A novel detection method of endocrine disrupting chemicals (EDCs) is proposed. Liposomes encapsulating fluorescence dye was prepared as a cell membrane model and applied to detect EDCs. Leakages of dye from liposomes were observed after their exposure to EDCs. Fluorescence intensity increased significantly when the liposomes were exposed to 5 ppm EDCs. The increases showed a good correlation with EDCs' dipole moment. Therefore, polarizability is suggested as one of the factors of the liposome-EDC interaction. At lower than 5 ppm, the increases depended on EDCs' concentration. The tendency of the results was in accordance with reported estrogenic activity of EDCs.

Notes

a Hansch et al. (Citation1995).

b IPCS 2008.

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