Electrochemical Investigation of Calcium Dobesilate and Interactions with Bovine Serum Albumin on Gold Nanoparticle–Modified Glassy Carbon Electrode

Abstract

The electrochemical behavior of calcium dobesilate (CD) and its interaction with bovine serum albumin (BSA) have been investigated, and the stoichiometric coefficient and association constant between CD and BSA were obtained. It was found that gold nanoparticles have a strong electrocatalytic effect on CD. With the addition of BSA in CD solution, both the oxidation and reduction currents decreased, but the peak potentials stayed almost unchanged. Non-electrochemical-active supramolecular complex BSA-CD_m was formed via the reaction of CD with BSA. This makes it feasible for CD to be used as an electrochemical probe for determining the concentration of BSA.

Keywords:

• Bovine serum albumin
• calcium dobesilate
• gold nanoparticles
• modified electrode

Acknowledgments

The author thanks the Laboratory for Special Functional Materials, Henan University, China, for financial support of this research.