Applicability of Derivative Spectrophotometry, Bivariate Calibration Algorithm, and the Vierordt Method for Simultaneous Determination of Ranitidine and Amoxicillin in Their Binary Mixtures

Abstract

Ultraviolet (UV)–derivative spectrophotometry, bivariate calibration algorithm, and Vierodt methods were applied to simultaneous determination of ranitidine (R) and amoxicillin (AMX) in binary mixtures. The first-order derivative allows determination of R in the concentration range 4.0 · 10⁻⁶ mol · dm⁻³ to 6.0 · 10⁻⁵ mol · dm⁻³. Vierordt method enables Ranitidine assaying in the presence of 2.5-fold excess of AMX and 3-fold excess of R. The bivariate calibration method obeys Beer's law in the concentration ranges 4.0 · 10⁻⁶ mol · dm⁻³ to 6.0 · 10⁻⁵ mol · dm⁻³ for R and 2.0 · 10⁻⁶ to 2.0 · 10⁻⁵ mol · dm⁻³ for AMX.

Keywords:

• Amoxicillin
• bivariate calibration method
• derivative spectrophotometry
• ranitidine
• UV determination
• Vierordt method

Notes

*in ratio to declared value