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Abstract
New diphenylpyraline (Di) ion selective plastic membrane electrodes for both conventional and coated wire types based on the ion associate of Di-HCl with sodium tetraphenylborate (NaTPB) and phosphotungestic acid (PTA) were prepared. The conventional type electrode was fully characterized in terms of membrane composition, plasticizer, filling solution, life span, pH, ionic strength, and temperature. The membranes of optimum compositions were used for the preparation of both graphite and cupper coated wire electrodes. The prepared electrodes were used for the potentiometric determination of the investigated drug in raw material and pharmaceutical preparations under batch and flow injection analysis conditions. The selectivity of the electrodes towards a large number of excipients like inorganic cations, sugars, and amino acids was tested. In addition, the determination of Di-HCl, the solubility product of the ion associate and the formation constant of the precipitation reaction leading to the ion associate formation were carried out using a conductimetric technique based on its ion association with NaTPB and PTA.
Notes
a Separate solution method.
b Mixed solution method.
c
cannot be determined using mixed solution method due to the precipitation of AgCl.
a Weight found (mg).
b Recovery (%).
c Standard deviation.
a Weight found (mg).
b Recovery (%).
c Standard deviation.
a Recovery.
b Standard deviation.
a Recovery (%).
b Standard deviation.
a Weight found (mg).
b Recovery (%).
c Standard deviation.
a Weight found (mg).
b Recovery (%).
c Standard deviation.
*Regression analysis (found values vs. taken) ideal values are 1.00 and zero for slope and intercept respectively.
**(n = 4) for the proposed methods and (n = 6) for HPLC method.