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Abstract
The development of advanced biosensor devices for very sensitive detection is highly required for many applications. The careful design of the bio-interface on the transducer surface is known to be one of the major bottlenecks for the development of high performance sensing devices. This paper reviews the emerging role of nanopatterned surfaces as alternative bio interface in the field of bio-detection. The different material used to functionalize this type of surfaces and the fabrication methodologies are described. Finally, the application of these surfaces in bio-detection using different biological systems and detection techniques is presented. In particular, a recent and very promising approach based on the optical interaction of nanoarrays with Surface Plasmon Resonance detection is described.
This article was submitted as part of a Special Memorial Issue honoring Prof. George G. Guilbault.