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Abstract
ApH dependent solvent extraction system has been developed to separate tolbutamide and its two known metabolites formed in man. The separated components are quantitatively converted into N-butyl-2, 4-dinitroaniline and can be measured either colorimetrically, when the concentrations are greater than 10 μg/ml of biological fluid, or via gas chromatography with electron capture detection, when the concentrations are less than 10 μg/ml. Plasma concentrations and excretion rates of drug and metabolites following intravenous administration of 1.0 g tolbutamide to man is reported.