Liquid Membrane Electrodes for the Potentiometric Determination of Scopolamine Hydrobromide and N-Butyl Scopolammonium Bromide

Abstract

Liquid-membrane electrodes sensitive to scopolamine⁺ and N-butyl scopolammonium⁺ are described for the direct or indirect assay of scopolamine hydrobromide and N-butyl scopolammoniumbromide, respectively, in pharmaceutical preparations. All electrodes exhibit a linear response to respective organic cation over the range of lo⁻¹ to lo⁻⁴ M. No interference from the common imgredient substances was observed.

Key Words:

• Ion-selective electrodes in liquid-state
• scopolamine hydrobromide
• N-butyl scopolammonium bromide
• pharmaceutical preparations
• direct potentiometry
• potentiometric titration