A Simple Photometric Assay of Papaverine in Dosage Forms

Mohamed S. Karawya Department of Pharmacology, National Research Centre Dokki, Cairo, Egypt.

Aly Mohamed Diab Department of Pharmacology, National Research Centre Dokki, Cairo, Egypt.

Nagla Z. Swelem Department of Pharmacology, National Research Centre Dokki, Cairo, Egypt.

Abstract

The method depends upon reducing papaverine with Zn/HC1 to a secondary base which could interact with fluoranil giving a charge-transfer complex with two prominent absorption maxima (350 and 530 nm). The method suits control analysis of papaverine-containing pharmaceuticals. The measured color is relatively stable, obeyed Beer's law (20-200 μg/ml° and showed % average recovery of 98.88 + 0.9.

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A Simple Photometric Assay of Papaverine in Dosage Forms

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A Simple Photometric Assay of Papaverine in Dosage Forms

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