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Analytical Letters Volume 18, 1985 - Issue 1
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Pharmaceutical Analysis

The Titrimetric Determination of 4-Pyridine Carboxylic Acid Hydrazide (Isoniazid) in Drug Formulations with Thallium (III)

Krishna K. Verma Department of Chemistry, University of Jabalpur, Jabalpur, 482001, India
&
Sandhya Palod Department of Chemistry, University of Jabalpur, Jabalpur, 482001, India
Pages 11-19 | Received 20 Jul 1984, Accepted 01 Oct 1984, Published online: 06 Dec 2006
 
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Abstract

Thallium (III) sulfate in dilute sulfuric acid quantitatively oxidizes isoniazid to nitrogen and 4-pyrldine carboxylic acid. The test material is reacted with a measured excess of the reagent, the residual amount being back-titrated with ascorbic acid using o-dianisidine or p-ethoxychrysoidine as indicator. 4-Aminosalicylic acid, thiacetazone, thiamine hydrochloride, lactose and a number of other excipients do not Interfere with the analysis.

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Related Research Data

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