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Analytical Letters Volume 19, 1986 - Issue 11-12
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PHARMACEUTICAL ANALYSIS

Spectrophotometric Determination of Nitrofurazone

Y. K. Agrawal Pharmacy Department, Faculty of Technology and Engineering, M. S. University of Baroda, Kalabhava, Baroda, 390 001, India
&
D. R. Patel Pharmacy Department, Faculty of Technology and Engineering, M. S. University of Baroda, Kalabhava, Baroda, 390 001, India
Pages 1289-1296 | Received 07 Apr 1986, Accepted 14 May 1986, Published online: 06 Dec 2006
 
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Abstract

A new sensitive and seleactive method for rapid and accurated determination of nitrofarazone is described. The nitrofurazone is reacted with hydroxyl-amine hydrochloride in alkaline medium to give hydroxamic acid which forms the purple violet coloured complex with iron (III), FeCl3, in acidic medium. The nitrofurazone was determined in presence of commonly used drugs and additives. The results obtained by the proposed and B.P. methods were compared.

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