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Abstract
A new spectrophotometric method for the determination of piroxicam has been developed. the method depends on the reaction of piroxicaam with copper (II) and iron (III) in methanolic hydrochloric acid solution where piroxicam is found to form 1:1 complexes with both metal ions with maximum absorption at 372 nm and 527 nm. Average log. stability constants of 4.872 and 4.546 were obtained for piroxicam-copper (II) and piroxicam-iron (III) complexes, respectively.
The method was successfully applied for the determination of piroxicam in pharmaceutical preparations. the validity of the method was checked by applying the standard addition technique in addition to a comparison study between its results and those obtained by the manufacturers' method.