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Analytical Biochemistry and Clinical Analysis

Quantitative Densitometric Determination of Theophylline

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Pages 827-839 | Received 02 Sep 1988, Accepted 19 Jan 1989, Published online: 23 Oct 2006
 

Abstract

A method for identification and quantification of theophylline in certain dosage forms, that employs TLC-scanner is reported. the method is applied for theophylline either as raw material or in certain dosage forms admixed with other medicamenta. Samples were extracted with methanol, separated and measured in situ on silica gel G plates at about 270 nm using TLC-scanner. the mean recovery (six determinations) was 99.9± 0.57. the developed procedure has been found to be simple, rapid and precise and its application to various dosage forms was demonstrated and yields comparable results with UV measurement after location, scraping and elution from the plates.

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