Determination of Potassium Guaiacolsulphonate In A Cough Syrup Using Second Derivative Spectrophotometry

Abstract

Potassium guaiacolsulphonate has been determined in a cough syrup by recording the second (D2) derivative absorption curve and taking D2 at 288 nn as a direct measure of its concentration. the mean percentage found from the labelled +SD was found to be 103.3+0.35. Added recovery experiments gave a mean percentage recovery of 100.3+0.24. the results were found to be in good agreement with those obtained using a spectro-fluorimetric method. the D2 method has been found to be reproducible with a relative standard deviation less than 1%.

Key Words:

• Guaiacolsulphonate
• Cough Syrup
• Derivative Spectrometry