Porous Chiral Metal-Organic Framework InH(D-C₁₀H₁₄O₄)₂ with Anionic-Type Diamond Network for High-Resolution Gas Chromatographic Enantioseparations

Abstract

Metal-organic frameworks have large surface area, highly ordered pore structure and good chemical stability. In this study, a porous chiral metal-organic framework InH(D-C₁₀H₁₄O₄)₂(D-C₁₀H₁₄O₄ = D-(+)-camphoric acid) with a left-handed helical channel assembled from D-(+)-camphoric acid was used as chiral stationary phase in GC. InH(D-C₁₀H₁₄O₄)₂-coated open tubular columns with different inner diameters or lengths were prepared by a dynamic coating method for high-resolution GC separation of various types of organic compounds, including racemates, isomers, alkanes, alcohols, and Grob's test mixture. Their column efficiency, polarity, and selectivity were studied. The experimental results show that the stationary phase has excellent selectivity and also possesses good recognition ability toward these organic compounds, especially for chiral compounds.

Keywords:

• Chiral separation
• Gas chromatography
• Metal-organic frameworks
• Porous chiral materials
• Stationary phase

Acknowledgments

This work was supported by the National Natural Science Foundation (No. 21075109, No. 21127012) and the National Basic Research Program (No. 2011CB612312) of China.

Notes

x′, benzene; y′, 1-butanol; z′, 2-pentanone; u′, nitropropane; s′, pyridine.

^a trifluoroacetyl derivate.

^b Trifluoroacetyl isopropyl ester derivate.