121
Views
3
CrossRef citations to date
0
Altmetric
MASS SPECTROMETRY

Stable Isotope Fingerprinting for Pharmaceutical Authentication

, , &
Pages 2691-2698 | Received 25 Aug 2016, Accepted 23 Nov 2016, Published online: 05 Sep 2017
 

ABSTRACT

The 13C stable isotopic composition of 38 pharmaceutical products was investigated for six medicine analgesics classes ibuprofen, diclofenac, paracetamol, metamizole, ketoprofene, and combinations containing paracetamol to evaluate differences between manufacturers and production batches. Complementary measurements were performed by inductively coupled plasma-mass spectrometry. Linear discriminant analysis was applied on experimental obtained data set for differentiation of three investigated drug types. The carbon isotopic compositions were between −32.9 and −22.6‰. The lowest values of 13C (mean of −31.3‰) were obtained for metamizole from all six categories of investigated analgesics. The highest δ13C values were obtained for diclofenac (mean of −25.9‰). The most accurate elemental predictors were V, Al, Sb, As, Pb, and Mn.

Additional information

Funding

The financial support for this work was provided by the National Authority for Scientific Research and Innovation, Program NUCLEU, contract no. PN16-300101.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.