Determination of Sulfamerazine in River Water Using Thermoresponsive Modified Silica for Solid-Phase Extraction with High-Performance Liquid Chromatography Detection

ABSTRACT

Four thermoresponsive silica-poly(N-isopropylacrylamide-co-butyl methacrylate) materials were prepared by grafting (N-isopropylacrylamide-co-butyl methacrylate) at different ratios on multimodal porous silica via surface-initiated atom transfer radical polymerization. The thermoresponsive materials were employed as the adsorbent for the rapid determination of sulfamerazine in river water by solid-phase extraction. The properties of silica-poly(N-isopropylacrylamide-co-butyl methacrylate) were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. Static adsorption measurements showed that the silica-poly(N-isopropylacrylamide-co-butyl methacrylate)₃ material had the highest adsorption characteristics (8.72 mg g⁻¹) at 35°C. The solid-phase extraction conditions were optimized, including the elution solvent and its volume used. The thermoresponsive silica-poly(N-isopropylacrylamide-co-butyl methacrylate)₃ material provided satisfactory results for solid-phase extraction, with a recovery of 90.06%, allowing the rapid purification of sulfamerazine in river water.

KEYWORDS:

• High-performance liquid chromatography
• N-isopropylacrylamide
• silica
• solid-phase extraction
• sulfamerazine
• thermoresponsive

Additional information

Funding

This work was supported by the Tianjin Municipal Natural Science Foundation of China [grant number 15JCQNJC43100 and 17JCYBJC19600], and it was also supported by Training Project of Innovation Team of Colleges and Universities in Tianjin.