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Voltammetry

Rapid Determination of 5-Nitrofuran Ring Antibiotics in Complex Samples Using a Boron-Doped Diamond Electrode and Differential Pulse Voltammetry

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Pages 2363-2375 | Received 04 Nov 2020, Accepted 07 Dec 2020, Published online: 21 Dec 2020
 

Abstract

A rapid, simple, and precise electrochemical method was developed for the determination of the total content of antibiotics containing a 5-nitrofuran ring with antibacterial activity including furazolidone, nitrofurazone, nitrofurantoin, and furaltadone in several samples. Boron-doped diamond electrode was used as the working electrode. The electrochemical properties of these compounds were evaluated by cyclic voltammetry. A differential pulse voltammetric method based on the cathodic reduction at high potentials was used for the determination of the total nitrofuran content in a mixture at pH 6.47. The voltammetric measurements showed that the proposed electrochemical method was able to identify the nitrofurazone from a mixture of antibiotics based on its anodic oxidation in alkaline medium (pH 10.6). This method presented good accuracy (between 94.5 and 102.5%) and precision (less than 3.94%), with calibration graphs starting from 50 nmol L−1. The method was applied with success for the determination of total content of compounds with 5-nitrofuran ring and for the selective determination of nitrofurazone in pharmaceutical tablets and food products (milk and honey) without pretreatment of the samples.

Disclosure statement

The authors have no conflicts of interest.

Additional information

Funding

This work was financed by the Romanian Department of Education and Research (MEN-UEFISCDI) projects: 22PFE/2018 (Program 1-Projects for Excellence Financing) and BIODIVERS 3 (Nucleu).

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