Square Wave Voltammetric (SWV) Determination of Cyanocobalamin (Vitamin B12) in Pharmaceuticals and Supplements on a Carbon Paste Electrode (CPE) Modified by a Manganese(II) Polymeric Film

Abstract

Here is described the fabrication and the electrochemical characterization of a newly modified carbon paste electrode with a manganese complex film possessing thiophene-2-carboxylic acid and triethanolamine as ligands. This electrode was used for the electrochemical determination of cyanocobalamin (vitamin B₁₂). A selective, low cost and low detection limit assay of vitamin B₁₂ was developed using square wave voltammetry. Potential interferents were determined and the results showed that they did not affect the analysis, indicating the selectivity of the proposed assay. This methodology was also applied to the determination of cyanocobalamin in tablets and dietary supplements, showing that the proposed electrochemical sensor was promising for routine analysis.

Keywords:

• Carbon paste electrode (CPE)
• cyanocobalamin (vitamin B₁₂)
• square wave voltammetry (swv)
• thiophene-2-carboxylic acid
• triethanolamine

Conflicts of interest

The authors declare no conflicts of interest.