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Abstract
Optimization based on the function of mutual information (FUMI) is reviewed by comparison with optimization of Rs in column chromatography. The following variables are considered: mobile phase composition; pH; column length; the amount of internal standard; detection wavelength. FUMI is equivalent to the precision of measurements and takes a maximum at the optimal condition. However, Rs neither takes a maximum nor corresponds to the precision. This paper demonstrates that FUMI is a superior measure of chromatographic performance.