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Analytical Letters Volume 24, 1991 - Issue 2
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Original Articles

Light Addressable Potentiometric Biosensor for the Detection of Anticholinesterases

Kim R. Rogers Department of Pharmacology and Experimental Therapeutics, University of Maryland, School of Medicine, Baltimore, MD, 21201
,
Marlene Foley Environmental Technologies Group Inc., 1400 Taylor Avenue, Baltimore, MD, 21039
,
Stephen Alter Environmental Technologies Group Inc., 1400 Taylor Avenue, Baltimore, MD, 21039
,
Philip Koga Environmental Technologies Group Inc., 1400 Taylor Avenue, Baltimore, MD, 21039
&
Mohyee Eldefrawi Department of Pharmacology and Experimental Therapeutics, University of Maryland, School of Medicine, Baltimore, MD, 21201
Pages 191-198 | Received 15 Oct 1990, Accepted 27 Nov 1990, Published online: 23 Oct 2006
 
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Abstract

Biotinylated acetylcholinesterase (AChE) from Eel was immobilized to a biotinylated cellulose nitrate membrane via a streptavidin bridge. Using a light addressable potentiometric sensor (LAPS), enzyme activity was determined as a function of substrate concentration (i.e. acetylcholine) and amount of enzyme immobilized to the membrane. This biosensor was also evaluated for its potential to detect organophosphate (OP) anticholinesterases (antiChEs).

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