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Analytical Letters Volume 25, 1992 - Issue 12
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Pharmaceutical Analysis

Voltammetric Behaviour of CRE-319, A Novel Dihydropyridine Calcium Antagonist and Its Polarographic, UV Spectrophotometric and HPLC Determination

J. A. Squella Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile, Casilla 233, Santiago-1, Chile
,
M. Ordenes Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile, Casilla 233, Santiago-1, Chile
,
F. Nocera Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile, Casilla 233, Santiago-1, Chile
,
C. Sunkel Alter. S. A. Mateo Inurria 30, 280036, Madrid, España
&
Luis J. Núñez-Vergara Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile, Casilla 233, Santiago-1, Chile
Pages 2225-2237 | Received 08 Jun 1992, Accepted 04 Aug 1992, Published online: 23 Sep 2006
 
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Abstract

CRE-319, a novel 1, 4-dihydropyridine derivative, produces a cathodic polarographic peak due to the reduction of its nitro group according to the following well-known general pathway for the nitro group:

The electrode mechanism is strongly dependent on the pH of the solution and follows a similar behaviour to that previously reported for nitrobenzene.

The peak current shows a linear dependence with CRE-319 concentrations. This behaviour is used for analytical purposes in determining CRE-319 content in solution. In order to obtain comparative results, we have also developed a spectrophotomebic and an HPLC method for quantifying CRE-3 19.

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