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Analytical Letters Volume 26, 1993 - Issue 10
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Pharmaceutical Analysis

Determination of Ofloxacin in Pharmaceutical Forms by High - Performance Liquid Chromatography and Derivative Uvspectrophotometry

G. Carlucci Dipartimento di Chimica, Ingegneria Chimica e Materiali dell'Università dell'Aquila, via Assergi 6, 67100, L'Aquila, (Italy)
,
P. Mazzeo Dipartimento di Chimica, Ingegneria Chimica e Materiali dell'Università dell'Aquila, via Assergi 6, 67100, L'Aquila, (Italy)
&
T. Fantozzi Dipartimento di Chimica, Ingegneria Chimica e Materiali dell'Università dell'Aquila, via Assergi 6, 67100, L'Aquila, (Italy)
Pages 2193-2201 | Received 18 Feb 1993, Accepted 06 May 1993, Published online: 23 Sep 2006
 
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Abstract

A method for the determination of ofloxacin in pharmaceutical forms is described. The procedure is based on the use of the high-performance liquid chromatography, and of the second-derivative ultraviolet spectra, by utilizing the linear relationship between substance concentration and derivative peak amplitude. The minimum concentration detectable by derivative spectrophotometry was 20 ng/ml, and by HPLC 10 ng/ml. The proposed methods, which give thoroughly comparable data, are simple and rapid, and allow precise and accurate results.

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