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Analytical Letters Volume 26, 1993 - Issue 11
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Bioanalytical

Extractionless HPLC Method for the Determination of Naproxen in Human Plasma and Urine

Th. Karidas Laboratory of Pharmaceutical Technology, University of Thessaloniki, Thessaloniki, 54006, Greece
,
A. Avgerinos Laboratory of Pharmaceutical Technology, University of Thessaloniki, Thessaloniki, 54006, Greece
&
S. Malamataris Laboratory of Pharmaceutical Technology, University of Thessaloniki, Thessaloniki, 54006, Greece
Pages 2341-2348 | Received 03 May 1993, Accepted 14 Jun 1993, Published online: 23 Sep 2006
 
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Abstract

A simple and rapid (extractionless) high-performance liquid chromatographic method with ultraviolet detection, at 278 nm, is described for the determination of naproxen in human plasma and urine. Niflumic acid is used as internal standard. The chromatographic system consists of a reversed-phase C18-Spherisorb column with acetonitrile/0.1 M sodium acetate (35:65 v/v, pH 6.14) as the mobile phase. The retention time is 3.0 min for naproxen and 3.8 min for niflumic acid. The total run time is 5 min and the typical assay time is 10 min. The method is sufficiently sensitive for biopharmaceutical studies, after the oral administration of a single sustained release dose.

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