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Analytical Letters Volume 26, 1993 - Issue 11
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Pharmaceutical Analysis

New Rapid Assay for Nafcillin by Spectrofluorimetry in Pharmaceutical Dosage

J. A. Murillo Department of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, 13071, Ciudad Real, (Spain)
&
A. Alañón Department of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, 13071, Ciudad Real, (Spain)
Pages 2409-2420 | Received 16 Apr 1993, Accepted 14 Jun 1993, Published online: 23 Sep 2006
 
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Abstract

A method for the spectrofluorimetric determination of nafcillin is proposed (λex = 226 nm, λem = 366 nm), for concentrations between 0.10 and 1.0 μg mL−1. The method was performed in ethanol/water medium (30% V/V), at apparent pH 6.0 provided by adding of phosphate buffer solution with pH = 6.20.

The obtained values of detection and determination limits are 0.016 and 0.054 μg mL−1, respectively.

The method was successfully applied to assay a commercial injection containing nafcillin sodium monohydrate.

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