Advanced search
Publication Cover
Analytical Letters Volume 26, 1993 - Issue 8
Submit an article Journal homepage
9
Views
12
CrossRef citations to date
0
Altmetric
Pharmaceutical Analysis

Spectrophotometric Determination of Certain Phenothiazines and Their Dosage Forms Using Bromophenol Blue

M. M. El-kerdawy Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
,
M. A. Maustafa Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
,
S. M. El-Ashry Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
&
D. R. El-Wasf Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Pages 1669-1680 | Received 11 Dec 1992, Accepted 03 Mar 1993, Published online: 23 Sep 2006
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

A simple and rapid spectrophotometric method for the determination of seven phenothiazine derivatives has been performed either in pure form or in their dosage forms. The method is based upon the interaction of the drug in dry chloroform with bromophenol blue in the same solvent to produce a stable yellow ion-pair complex which absorbs at 410 nm, with high apparent molar absorptivity. Beer's Law is obeyed in the concentration range 1−10 ugml−1 for the studied compounds. The mean recoveries range from 99.80±0.74 to 100.50±1.33. The proposed method is applied for the analysis of the studied compounds in their commercial preparations. Results are in good agreement with those obtained by official methods.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Evaluation of certain pharmaceuticals with hexa-amminecobalt(III) tricarbonatocobaltate(III)-I Determination of some N-substituted phenothiazine derivatives.
Source: Elsevier BV
Fluorimetric Determination of Certain Phenothiazine Derivatives Using Eosin
Source: Informa UK Limited
Determination of phenothiazine drugs by HPLC with electrochemical detection.
Source: Japan Society for Analytical Chemistry
Automated flow injection spectrophotometric determination of some phenothiazines using iron perchlorate: applications in drug assays, content uniformity and dissolution studies
Source: Royal Society of Chemistry (RSC)
Spectrophotometric titration of phenothiazines using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone
Source: Springer Science and Business Media LLC
Determination of phenothiazines by charge-transfer complex formation with chloranilic acid
Source: Elsevier BV
Colorimetric Determination of Some N-Substituted Phenothiazine Derivatives Using 2-Iodoxybenzoate
Source: Informa UK Limited
Spectrophotometeric determination of some N -substituted phenothiazine derivatives using N -bromophthalimide
Source: Springer Science and Business Media LLC

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.