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Abstract
A rapid, specific and reliable high performance liquid chromatographic assay of Metoclopramide in tablets has been developed. Reversed-phase chromatography was conducted using a mobile phase of acetate buffer and acetonitrile, (75% v/v) and detection at 273nm. The recovery and coefficient of variation from six placebo tablets containing 10 mg of Metoclopramide were 100.5% and 0.889% respectively. Relicate regression analyses of three standard plots in the concentration range of 0.5 – 7 mcg/mL obtained on three different days gave a correlation coefficient > 0.996 and the coefficient of variation of the slopes < 1%. The assay was precise within day and between days as indicated by ANOVA test. The recoveries from 10 replicate tablets of three different commercial Metoclopramide brands was 98.7, 100.8 and 100.3% of the label amount and their coefficients of variation were 1.16, 1.76 and 1.6%.