Spectrophotometric Determination of Niclosamide and Thiabendazole in Tablets

Abstract

In this study, determination of niclosamide and thiabendazole in their binary mixture was realized by precipitating thiabendazole with ammonium reineckate at pH:3 selectively and reading the absorbance of the solution of the precipitate in acetone at 525.0 nm for thiabendazole and by measuring the dA/dΔ values at 405.8 nm in the first derivative spectra of the remaining solution for niclosamide. The relative standard deviation of the method was found to be 1.16 % for thiabendazole and 0.75 % for niclosamide. Recoveries were found to be 100.1 % and 98.8 % for thiabendazole and niclosamide respectively. The method has been succesfully applied to a tablet containing thiabendazole and niclosamide.

Key Words:

• Niclosamide
• thiabendazole
• pharmaceutical preparation
• spectrophotometry