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Abstract
The reaction of lincomycin with cupric ions in alkaline medium was taken as a basis for the colorimetric and indirect atomic absorption spectrometric (AAS) determination of lincomycin hydrochloride.
The AAS procedure was based on the extraction of copper-lincomycin complex at pH 11, into n-butanol. The copper content in this extract was determined by AAS. The response was linear for up to 30 μg ml−1 of lincomycin. The method is accurate, sensitive and simple.
The proposed methods were applied to pharmaceutical preparations with fine accuracy.