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Abstract
A plasticised PVC Ion-Selective membrane electrode responsive for glafenine cation has been developed. It is based on the use of the ion-associate species, formed by glafenine cation and tetraphenylborate counterion. The basic electrode performance characteristics are evaluated according to IUPAC recommendations. It exhibited a linear response for 1 x 10−2 1x 10−4 M of glafenine solutions with a cationic Nernstian slope over the pH range 1–3.5. Common organic and inorganic cations showed negligible interference. Direct potentiometric determination of 9.8 X 10−5 - 9.8 x 10−3 M aqueous glafenine hydrochloride using this membrane electrode system showed an average recovery of 99.3% with a mean standard deviation of 1.5%. This electrode system was successfully used for monitoring the titration of glafenine with sodium tetraphenyl borate and for determining glafenine in some pharmaceutical formulations.