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Abstract
We determined serum bretylium levels using a bretylium-selective electrode, constructed by incorporating sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate as an ion-exchanger and 2-fluoro-2′-nitrodiphenyl ether as a solvent mediator in a poly(vinyl chloride) membrane matrix. The detection limit was 0.4 μM and the sensitivity completely covered the bretylium concentration range (2-12 μM) required for antiarrhythmic therapy. The results correlated well with those obtained by conventional gas chromatographic analysis. The potentiometric procedure is simple, rapid, economical and, thus, useful for therapeutic drug monitoring in a clinical setting.