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PHARMACEUTICAL ANALYSIS

Voltammetric Behaviour of Ketorolac and Its HPLC-EC Determination in Tablets.

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Pages 553-564 | Received 25 Jul 1996, Accepted 23 Oct 1996, Published online: 21 Aug 2006
 

ABSTRACT

Ketorolac is an antiinflammatory-analgesic agent that is oxidizable at the glassy carbon electrode. The voltammetric oxidation produces two well resolved pH-dependent peaks, that are overlapped at pH>10. Using this voltammetric response a HPLC procedure with electrochemical detection in order to quantify ketorolac in pharmaceutical dosage forms is presented. Furthermore comparative methods using UV spectrophotometry and HPLC with photodiode array detector were used.

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